Fig 1: lncRNA OTUD6B-AS1 exacerbates As2O3-induced cytotoxicity in vivo. (a) Harvested xenotransplanted tumors following lncRNA OTUD6B-AS1 overexpression or treatment with 5 mg/kg As2O3. (b) Volume and (c) weight of the harvested tumors. (d) Levels of lncRNA OTUD6B-AS1 in harvested transplanted tumors determined by qRT-PCR. Bladder cancer xenograft tumors were stained with (e) H&E and (f) TUNEL. Scale bar: 50 μm. (g) Statistical analysis of cells positive for TUNEL staining in bladder cancer xenotransplanted tumors. Bladder cancer xenograft tumors were evaluated by immunohistochemistry staining using antibodies against (h) Ki-67 and (i) p57. Scale bar: 50 μm. ∗P < 0.05, ∗∗P < 0.01 vs. control xenotransplanted tumors; #P < 0.05, ##P < 0.01 vs. transplanted tumors with lncRNA OTUD6B-AS1 overexpression; &P < 0.05, &&P < 0.01 vs. transplanted tumors treated with 5 mg/kg As2O3.